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Showing posts with label life. Show all posts
Showing posts with label life. Show all posts

Sunday, March 22, 2015

Should I End My Life

Should I End My Life


Most of us (especially those who have seen a lot of ups and downs in life) at a certain point must have thought about ending your life. But do u really think that you have the right to end your life. Sometimes we are in so much physical or psychological pain that we think to end all that pain by ending ourselves. I expect your thoughts at the end of this article to get your views on this thing too. But at this time lets proceed with my views.

Our life outcome of someone elses effort. Those someone else are not just our parents, its not just our
mother or father. Those someone include our friends, brothers and sisters, our spouse, our children. Life is not just taking birth. Life is much more than that. Its also connected to a number of other lives. We are a just a part of a social network. Our one decision can make a lot of effects on lives of other people.

Sometimes we think that others dont like us, dont trust us, they dont need us any more. But its just our thinking (mostly for a few hours or days). Some of us make a very hard decision during that time. If we wait for a few more hours or speak to someone regarding our feelings then we might not take such step. We might think that no body need us, but there is always somebody who cant live without you, for whom you are very special. That special person may be your father , mother, friend, spouse, son or daughter. You might be thinking that that person dont need you anymore as he / she is angry with you. But it doesnt mean that he / she will live happily without you. If you love him / her then you will not want to make them unhappy and regret their one fight with you for their whole life.

Even if you think that that special person want to get rid of you, but you love him / her and want to fulfill his / her wish by ending your life. In that case there might be somebody else who need you much more than him / her.

We think that our life our own, but its not. it belongs to everybody who are part of your life. Just think about those who will feel lonely without you. Who loved you more than their own life, who struggled to make you a better person, who took you to doctors when you were ill, who wept when you were in pain, who wanted to make your life better, who spent their lives to make you something. It doesnt matter if you have reached you goal in life or not. But there are still chances. But if you end yourselves those chances will be gone. There is always a way towards better life. Dont let that chance end. HOPE is everything. Hope for better !
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Friday, March 20, 2015

Is Isopropyl Alcohol Rubbing Alcohol Its Uses in daily Life

Is Isopropyl Alcohol Rubbing Alcohol ?


Isopropyl alcohol, generally known as rubbing alcohol, is a dissolvable that is frequently utilized for cleaning or as a disinfectant. It is vital to note that this is not the same as ethanol which is the sort you can drink. Isopropyl alcohol is toxic and ought to never be ingested.

Rubbing alcohol, USP/ Surgical soul, B.P. is a fluid arranged and utilized principally for topical application. It is readied from an unique denatured alcohol arrangement and contains more or less 70 percent by volume of concentrated ethanol (ethyl alcohol) or isopropyl alcohol (propan-2-ol).

Uses of Rubbing Alcohol



As an Antiseptic

Isopropyl alcohol is often used as an antiseptic, and most of the doctors use it to disinfect your skin before injections to kill surface bacteria.

As an Astringent

It can shrink or tighten your body tissues, like the pores in your skin, when they are applied topically. It helps to give your skin a smoother look and make pores less visible. Astringents also help to stop bleeding in minor cuts and scrapes by tightening up the capillaries that are losing blood.

As Pain Killer for Muscle Aches

It can be rubbed over the surface of aching muscles or painful joints to help reduce pain and swelling. Alcohol is an effective Pain Killer because it acts as a minor irritant to the skin increasing circulation and blood flow to the area. This increased circulation helps to ease pain and inflammation.

Expel hair splash from mirrors 

When you are spritzing your head with hair splash, some of it inescapably winds up on the mirror. A fast wipe with rubbing alcohol will whisk away that sticky buildup and leave your mirror shimmering clean.

Clean venetian blinds 

Rubbing alcohol makes a marvelous showing of cleaning the supports of venetian blinds. To make brisk work of the occupation, wrap a level device — a spatula or perhaps a 6-inch (15-centimeter) drywall blade — in fabric and secure with an elastic band. Plunge in alcohol and go to work.

Keep windows shining and frost free 

Do your windows ice up in the wintertime? Wash them with a mixture of 1/2 cup rubbing alcohol and1 liter water to stop ice freezing on the glass. Clean the windows with daily paper after you wash them to make them sparkle.

Anticipate ring around the neckline 

To keep your neck from recoloring your shirt neckline, wipe your neck with rubbing alcohol every morning before you dress. Feels great as well.

Clean your telephone 

Is your telephone getting a bit dingy? Wipe it down with rubbing alcohol. Itll uproot the grime and sterilize the telephone in the meantime.

Uproot ink stains 

Did you get ink on your most loved shirt or dress? Soak the spot in rubbing alcohol for a couple of minutes before putting the piece of clothing in the clothes washer.

Erase permanent markers

Rubbing Alcohol can remove the marks the permanent marker very easily. Just put some rubbing alcohol on the mark for a few seconds and then wipe it. Do it twice or thrice will completely remove it from most of the surfaces like plastic laminates and tiles.

Uproot puppy ticks 

Ticks detest the taste of rubbing alcohol as much as they cherish the taste of your puppy. Before you pull a tick off Fido, touch the critter with rubbing alcohol to make it slacken its grasp. At that point get the tick as near to the puppys skin as you can and haul it straight out. Spot again with alcohol to sanitize the injury. This chips away at individuals as well.

Get rid of fruit flies

Fruit flies dont like the smell of rubbing alcohol. If you spray the rubbing alcohol using an empty perfume bottle, then it will do the work. However its less effective compared to some insecticide but its safer, as rubbing alcohol is not as poisonous as insecticide.

Make a shapeable ice pack 

The issue with ice packs is they wont adjust to the state of the harmed body part. Make a slushy, comparable pack by blending 1 section rubbing alcohol with 3 sections water in a closing toward oneself plastic sack. Whenever that sore knee misbehaves, wrap the sack of slush in a fabric and apply it to the zone.

Clean washroom installations 

Simply venture into the prescription bureau whenever you have to clean chrome lavatory installations. Pour some rubbing alcohol straight from the container onto a delicate, spongy fabric and the apparatuses. No compelling reason to wash — the alcohol simply vanishes. It makes an awesome showing of making chrome shimmer, in addition to it will murder any germs in it.
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Saturday, March 14, 2015

Optimal Live a Healthy Life Now!


Health is a very worthwhile investment. Therefore, make optimal healthy life as your daily habits. How? 15 Follow the following tips:

1. Meet the nutritional needs 

Consider the nutritional content of your food that contains complete composition, including carbohydrates, proteins, fats, vitamins and minerals.

2. Avoid harmful fats 

Not all fats are bad, because its important for you to pay attention to the type of fat you consume. Fried foods, butter and snacks often contain trans fats can increase the risk of heart disease. Healthy fats such as omega 3, 6, 9 it is able to reduce the risk of heart disease. Eat 3-4 servings of fish a week to increase your intake of healthy fats in your body. 

3. Do not forget breakfast 

In order to have enough energy, you perlusarapan every day. Even when you are in a weight loss program, breakfast is recommended. When the fear of weight gain, reduce carbohydrate servings at lunch and dinner to control calorie intake.

4. Eating enough fruits and vegetables 

Consumption of fruit and 5-7 servings of vegetables every day to help meet the needs of vitamins, minerals and fiber every day.

5. drink 

Since most of our body is water, meet the bodys need for water, at least 8 glasses a day.   

6. Maintain a healthy weight 

Underweight, as dangerous as being overweight. Therefore maintain your ideal weight. 

7. sport 

In addition to improving physical fitness, exercise can help the bodys metabolic processes. Do exercise 3-4 times a week with a duration of 1 hour. Select the appropriate sports body condition.

8. adequate rest 

Sleep is as important as food and air. Make sure you rest the body 6-8 hours a day so that the bodys cells can regenerate well.  

9. Avoid cigarette and alcoholic drink 

Cigarettes and alcohol have the effect of free radicals that are harmful to health. 

10. positive thinking 

It is important to avoid stress. Because stress can trigger the onset of the disease.

11. Take time for yourself 

Often busy makes you forget yourself. Take your time for hobbies to reduce stress that can damage the health. 

12. Note the cleanliness 

Bathing twice a day, wash your hands before eating and after the move, brush teeth twice a day, it could be a very simple step in maintaining your health.

13. Regular health check  

Check your health regularly, at least once a year to avoid potential disease early.

14. Choose natural materials 

Limit consumption of processed foods. Choose natural products as a source of food, beverages and natural suplemenkarena more acceptable to the body, as compared with chemical (synthetic).

15. supplements 

Many people do not get enough vitamins and certain nutrients due to diet and lifestyle is not good. Food supplements will help ensure the nutritional needs everyday. Choose in accordance with the conditions and needs of the body, and is made of quality natural ingredients that are safe for your health. 
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Saturday, March 7, 2015

Low Testosterone Low Life Expectancy Plus Chinese vs US Do the Same Reference Ranges Apply for Everyone

This is what Photoshop and creativity can tell us about aging men.
It has been a while since weve taken a closer look at the effects of testosterone deficiency and its replacement aka TRT. Basically thats why I decided not to waste the interesting findings from a recently published study in the The Journal of Clinical Endocrinology and Metabolism (Yeap. 2013) in the Facebook News. In combination with the findings Xu et al. report in a paper on the difference in testosterone concentrations in young healthy US versus Chinese men the Yeap study does after all make a decent addition to the 269 of hitherto ~1500 archived SuppVersity articles that deal in one way or another with the famous androgen.

Virile men live longer! Ca. 30% longer, to be precise.

If you take a look at the link between serum testosterone, free testosterone and DHT and the all-cause mortality risk of the 16,451 community-dwelling older men from Perth in Western Australia it should be obvious that the third quartile of all these serum values, is where you want your androgen levels to be, if you intend to live to see your 90th birthday.
Figure 1: Relative reduction in all-cause mortality with total and free testosterone levels, as well as dihydrotestosterone levels in quartile 2,3 & 4 vs. quartile 1 (Yeap. 2013)
To quantify: You want to have your total testosterone levels in the 12.56 – 15.75 nmol/L (362ng/dl - 454ng/dL), your free testosterone levels in the 182.66 – 216.34 pmol/L (5.3-6.2 ng/dL) and your dihydrotestosterone (DHT) levels in the 1.34 – 1.83 nmol/L (DHT; 39-53ng/dL) range if you dont want to miss a couple of years of your life.

Symptoms of low testosterone:
Somatic: Gynecomastia, de- creased body hair, hot flashes, decreased lean muscle mass, decreased strength, anemia, frailty, osteoporosis, easy fatigue, sleep disturbances, increased body fat or body mass index
Psychological: Depressed mood, irritability, emotional lability, impaired cognition and memory, decreased energy
Sexual: Diminished libido, erectile dysfunction, decreased nocturnal and morning erections, difficulty achieving orgasm, decreased performance (Traish. 2011).
And while your androgen levels shouldnt be significantly lower, you also dont want them in the fourth quartile, where the all-cause mortality risk begins to rise again. Unless you dont want to lose the ~30% all-cause mortality of being in the zone, you shouldnt let the rumors about a causal (not corollary) link between testosterone replacement therapy (TRT) and the incidence of prostate cancer upset you. Why, well because ...
"[...] to date, no study or review has definitively shown that androgen replacement therapy is an independent risk factor for development of prostate cancer." (Fisher. 2012) 
The thing you should ask yourself is thus whether you really want to give up on this 30% reduction in all-cause mortality, or the decrease in fatal cardiovascular events, Ramasay et al. list next to the reduction in body fat mass, and insulin resistance among the proven benefits of TRT in their 2012 review of the literature.

Its your decision and therefore you should make sure that its you and not your doctor who takes this decision. If you decide to help your low testosterone levels along, its your doctors job to help and assist you by ordering and interpreting regular hormone and, as Fisher et al. suggest, PSA tests.

Informed decisions, require information, lab values, and reference ranges!

Speaking about "interpreting" hormone panels. One of the problems youll be facing is that nobody can actually tell you what your normal testosterone level should look like. Of course, every med-school graduate will believe that he knew exactly whats good for you, but when its all said eand done, scientists (and doctors) tend to be a bit too egalitarian, when it comes to "normal ranges". So egalitarian, in fact that they simply assume that a lightweight Chinese pencil pusher must have the same testosterone levels as a 6.6 ft tall, 300lbs heavy Caucasian strongman.
Table 1: Normal ranges for total T.
How do we know what "normal" is? Actually we dont. I mean, if you look at the average American or Chinese men, neither his health, nor his physique, or intelligence are "optimal" and still they are the "norm" we use to gauge our testosterone levels. For young men, this is not that much of a problem, but accepting the reference ranges for old guys is - if you asked me - like surrendering to physical decline.
Figure 2: Total and bioavailable testosterone levels in US and Chinese young men (Xu. 2013)
Its thus quite refreshing that Xu et al. followed a different path and followed the heavily underused "Equal, but different!"-princple, when they decided to conuct what they claim is the first study to analyze and compare the total (TT), calculated free (FT), and bioavailable testosterone (Bio T) levels of healthy young men (18–29 years) from the Third National Health and Nutrition examination Survey (NHANES III) in the United States (US) to those of men living in a region of China with a similar living standard to the US, i.e., Hong Kong.

By this means, the researchers wanted to find out whether the potentially existing differences in androgen levels in Caucasian vs. Asian young men would warrant a revision / specification of the "normal" range for men from different ethnic backgrounds.

As you can see the results are not exactly easy to interpret (Figure 2) - is this a difference, or not?

If we take another look at the data in Figure 2 and compare the relative differences between the total testosterone levels of young US vs. Chinese men to those that made a significant difference, in the previously discussed study by Yeap et al. (see Figure 1), we will have to concede that the xisting differences can hardly be significant. They are after all a magnitude smaller than the quartiles in the Yeap study.
Free vs. total testosterone, measured vs. calculated: Direct measurement of free testosterone levels is different from using the total testosterone and SHBG levels (which were higher in US men, by the way; Xu. 2013) to calculate an estimated amount of free testosterone (cf. Vermeulen. 1999). Since its cheap and usually pretty accurate this is yet what most labs will do. You should however be aware that the values are accurate, only, if your SHBG and albumin values are "normal" as well. If those are out of range, its a good idea to get the free testosterone levels measured directly, to find out where you are standing.
That being said, there are at least three additional reason that speak against establishing specific testosterone cut-off values for different ethnic groups based on the Xu study:
  1. The Xu study is not representative of "all" Chinese young men: The Xu study compares US citizens in the US to Chinese citizens in China. Who tells us that the values they obtained for young Hong Kongers are valid for 2nd generation Chinese immigrants to the US, as well? Environmental conditions, dietary factors, etc. all that could just as well be the reason for the measured differences as ethnicity-specific genetic differences.
  2. The Xu study, or rather the NHANES data is not representative of a specific ethnicity: By analogy to (1), the Xu study, which uses data from NHANES III to gauge the average testosterone levels of male US citizens, relies on data from Asian, African American, Native American, Hispanic and Caucasian US citizens. How on earth would you establish ethnicity specific normal values based on that?
  3. Using the Yeap study as a reference to determine "optimal levels" is unwarranted: With old men as study participants, the significance of the optimal total testosterone levels from the Yeap study (12.56 –15.75 mmol/L ≡ 362- 454ng/dL) is about as questionable as the assumption that older men are actually supposed to have significantly lower testosterone levels.
And even if you wouldnt agree that these objections are valid, there would be a simple, yet effective solution to end this discussion once and for all: Measure (or calculate) the free testosterone levels!

If you do that, i.e. compare free instead of total testosterone levels, you will find that the purported ethnic differences disappear. And this is true not solely for the comparison of the data from Chinese and US men Xu et al. analyzed, but also for the existing differences between Mexican-American, non-Hispanic black and non-Hispanic white men in the NHANES study by Rohrmann et al. (2007). Specific reference ranges for Asian, Caucasian, African American, Hispanics, ... are thus probably unwarranted (not sure about Aliens, though ;-).
The age related decline in testosterone is rapid: Accoring to Morley, et al. the average rate of decrement in testosterone concen-tration for men aged 60+ is 110 ng/dL every decade. A "normal" Caucasian man, who would still have a testosterone level of 500ng/dl when hes sixty (Rohrmann. 2013) would thus end up at 280ng/dl, which is right in the "highest risk of all-cause mortality" quartile (Q1) of the Yep study.
Bottom line: Despite the fact that our insights into the non-existent, or at least insignificant ethnic differences in free and total testosterone levels confirm the validity of the currently propagated "normal" ranges for young men, we are still left with the implications of the Yeap study and the questionable usefulness of "age adjusted" testosterone levels.

If we take into account that the age-induced androgen decline correlates with the aforementioned increases in all cause and cardiovascular mortality (Yeap. 2013), as well as lower levels of handgrip, hip flexors, hip extensors and abductors strength (Perry III. 2000) and an increase risk of development metabolic syndrome (48% higher risk; cf. Rodriguez. 2007), it would certainly appear that any "age-adjustment" thats based on observations in the average aging male is bogus...but I guess thats a topic for another SuppVersity article ;-)
References: 
  • Ramasamy, R., Fisher, E. S., & Schlegel, P. N. (2012). Testosterone replacement and prostate cancer. Indian journal of urology: IJU: journal of the Urological Society of India, 28(2), 123.
  • Yeap, B. B., Alfonso, H., Chubb, S. P., Handelsman, D. J., Hankey, G. J., Almeida, O. P., ... & Flicker, L. (2013). In Older Men an Optimal Plasma Testosterone Is Associated With Reduced All-Cause Mortality and Higher Dihydrotestosterone With Reduced Ischemic Heart Disease Mortality, While Estradiol Levels Do Not Predict Mortality. 
  • Perry III, H. M., Miller, D. K., Patrick, P., & Morley, J. E. (2000). Testosterone and leptin in older African-American men: relationship to age, strength, function, and season. Metabolism, 49(8), 1085-1091. 
  • Rodriguez, A., Muller, D. C., Metter, E. J., Maggio, M., Harman, S. M., Blackman, M. R., & Andres, R. (2007). Aging, androgens, and the metabolic syndrome in a longitudinal study of aging. Journal of Clinical Endocrinology & Metabolism, 92(9), 3568-3572.
  • Rohrmann, S., Nelson, W. G., Rifai, N., Brown, T. R., Dobs, A., Kanarek, N., ... & Platz, E. A. (2007). Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans. Journal of Clinical Endocrinology & Metabolism, 92(7), 2519-2525.
  • Traish, A. M., Miner, M. M., Morgentaler, A., & Zitzmann, M. (2011). Testosterone deficiency. The American journal of medicine, 124(7), 578-587. 
  • Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999). A critical evaluation of simple methods for the estimation of free testosterone in serum. Journal of Clinical Endocrinology & Metabolism, 84(10), 3666-3672.
  • Xu, L., Au Yeung, S. L., Kavikondala, S., Leung, G. M., & Schooling, C. M. (2014). Testosterone concentrations in young healthy us versus Chinese men. American Journal of Human Biology, 26(1), 99-102.
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